IN VITRO AND IN VIVO PRECLINICAL VENOM INHIBITION ASSAYS IDENTIFY METALLOPROTEINASE INHIBITING DRUGS AS POTENTIAL FUTURE TREATMENTS FOR SNAKEBITE ENVENOMING BY DISPHOLIDUS TYPUS

Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa.Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors and deplete fibrinogen.The only available treatment

Invasive fungal infections are an increasingly important cause of human morbidity and mortality.We generated a next-generation sequencing (NGS)-based method designed BATH BOMB GLOW to detect a wide range of fungi and applied it to analysis of the fungal microbiome (mycobiome) of the lung during fungal infection.Internal transcribed spacer 1 (ITS1)

Educational scholars generally agree that educational policies are inevitably regarded as one of the most contested areas in education.On the one hand, democracy requires more involvement on the part Tumbler of the citizens.At the most ideal level, democratic mechanisms have been developed to allow more people to more fruitfully participate in deci

ABSTRACT Studies carried out over short time intervals assist in understanding the biogeochemical processes occurring relatively fast in natural waters.High frequency monitoring shows a greater variability in the water quality during and immediately after heavy rainfall events.This paper presents an assessment of the surface water quality parameter

In the Atacama Desert, the spectral distribution of solar radiation differs from the global standard, showing very high levels of irradiation with a particularly high ultraviolet content.Additionally, the response of photovoltaic (PV) technologies is spectrally dependent, so it is necessary to consider local conditions and type of technology to opt